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Shargel, Leon, 1941-

Applied biopharmaceutics & pharmacokinetics / Applied biopharmaceutics and pharmacokinetics Leon Shargel, Andrew B.C. Yu, Susanna Wu-Pong. - 6th ed. - New York : McGraw-Hill, 2012. - p. ; cm.

Includes bibliographical references and index.

Introduction to biopharmaceutics and pharmacokinetics -- Mathematic fundamentals in pharmacokinetics -- One-compartment open model: intravenous bolus administration -- Multicompartmental models : intravenous bolus administration -- Intravenous infusion -- Drug elimination and clearance -- Pharmacokinetics of oral absorption -- Multiple-dosage regimens -- Nonlinear pharmacokinetics -- Physiologic drug distribution and protein binding -- Drug elimination and hepatic clearance -- Pharmacogenetics -- Physiologic factors related to drug absorption -- Biopharmaceutic considerations in drug product design and in vitro drug product performance -- Drug product performance, in vivo : bioavailability and bioequivalence -- Impact of drug product quality and biopharmaceutics on clinical efficacy -- Modified-release drug products -- Targeted drug delivery systems and biotechnology products -- Relationship between pharmacokinetics and pharmacodynamics -- Application of pharmacokinetics to clinical situations -- Dosage adjustment in renal and hepatic disease.

ISBN: 9780071603935 (hardcover : alk. paper) 007160393X (hardcover : alk. paper)

LCCN: 2011020446

Subjects--Topical Terms:
Biopharmaceutics.
Pharmacokinetics.
Biopharmaceutics.
Models, Chemical.
Pharmacokinetics.

LC Class. No.: RM301.4 / .S52 2012

Dewey Class. No.: 615/.7

National Library of Medicine Call No.: QV 38