Includes bibliographical references and index

Foundations of biochemistry -- Structure and catalysis: Water; Amino acids, peptides, and proteins; Three-dimensional structure of proteins; Protein function; Enzymes; Carbohydrates and glycobiology; Nucleotides and nucleic acids; DNA-based information technologies; Lipids; Biological membrane and transport; Biosignaling -- Bioenergetics and metabolism: Principles of Bioenergetics; Glycolysis, gluconeogenesis, and the pentose phosphate pathway; Principles of metabolic regulation, glucose and glycogen; Citric acid cycle; Fatty acid catabolism; Amino acid oxidation and the production of urea; Oxidative phosphorylation and photophosphorylation; Carbohydrate biosynthesis in plants and bacteria; Lipid biosynthesis; Biosynthesis of amino acids, Nucleotides, and related molecules; Hormonal regulation and integration of mammalian metabolism -- Information pathway: Genes and chromosomes; DNA metabolism; RNA metabolism; Protein metabolism; Regulation of gene expression -- Appendices: Common abbreviations in the biochemical research literature; Abbreviated solutions to problems -- Glossary

New edition of what is often considered the single best text on biochemistry, focusing on communicating to students the fundamentals of biochemistry in a way that reflects the field as it is understood today. Major recent advances covered range from the draft sequence of the human genome to elucidation of the high-resolution structure of the ribosome